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v-plex human il-2 assay kit  (Meso Scale Diagnostics LLC)

 
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    Meso Scale Diagnostics LLC v-plex human il-2 assay kit
    V Plex Human Il 2 Assay Kit, supplied by Meso Scale Diagnostics LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/v-plex+human+il-2+assay+kit/pmc10769863__pnas__2307086120__sapp-257-10-15?v=Meso+Scale+Diagnostics+LLC
    Average 90 stars, based on 1 article reviews
    v-plex human il-2 assay kit - by Bioz Stars, 2026-08
    90/100 stars

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    KPD model of mRNA‐6231 in nonhuman primates. HSA‐IL2m, human interleukin 2 mutein fused to human serum albumin, measured in plasma; SC, subcutaneous administration; K a , absorption rate constant; CL t , clearance of mRNA‐6231 from the transit compartment; HSA‐IL2m synthesis, rate of synthesis of HSA‐IL2m recombinant protein; <t>CL</t> <t>IL2</t> , clearance of HSA‐IL2m; k e 0 , effect compartment rate constant; KPD, kinetic‐pharmacodynamic; T reg , regulatory T measured in peripheral blood mononuclear cells.
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    KPD model of mRNA‐6231 in nonhuman primates. HSA‐IL2m, human interleukin 2 mutein fused to human serum albumin, measured in plasma; SC, subcutaneous administration; K a , absorption rate constant; CL t , clearance of mRNA‐6231 from the transit compartment; HSA‐IL2m synthesis, rate of synthesis of HSA‐IL2m recombinant protein; CL IL2 , clearance of HSA‐IL2m; k e 0 , effect compartment rate constant; KPD, kinetic‐pharmacodynamic; T reg , regulatory T measured in peripheral blood mononuclear cells.

    Journal: CPT: Pharmacometrics & Systems Pharmacology

    Article Title: Translational kinetic‐pharmacodynamics of mRNA‐6231, an investigational mRNA therapeutic encoding mutein interleukin‐2

    doi: 10.1002/psp4.13142

    Figure Lengend Snippet: KPD model of mRNA‐6231 in nonhuman primates. HSA‐IL2m, human interleukin 2 mutein fused to human serum albumin, measured in plasma; SC, subcutaneous administration; K a , absorption rate constant; CL t , clearance of mRNA‐6231 from the transit compartment; HSA‐IL2m synthesis, rate of synthesis of HSA‐IL2m recombinant protein; CL IL2 , clearance of HSA‐IL2m; k e 0 , effect compartment rate constant; KPD, kinetic‐pharmacodynamic; T reg , regulatory T measured in peripheral blood mononuclear cells.

    Article Snippet: Flow cytometry to assess the expansion of T regs used several markers including the IL‐2 [Human] V‐Plex Kit (MesoScale Discovery, Rockville, MD, K151QQ), CD25‐BV421 (clone M‐A251, BioLegend, San Diego, CA, 356114), CD16‐BV510 (Clone 3G8, BioLegend, San Diego, CA, 302042), CD4‐BV711 (clone OKT4, BioLegend, San Diego, CA, 317440), CD8‐BV785 (clone SK1, BioLegend, San Diego, CA, 344740), CD3‐AF488 (clone SP34‐2, BD Biosciences, Franklin Lakes, NJ, 557705), FoxP3‐PE (clone 206D, BioLegend, San Diego, CA, 320108f), CD14‐PerCP‐Cy5.5 (clone M5E2, BioLegend, San Diego, CA, 301824), CCR7‐PE‐Cy7 (clone G043H7, BioLegend, San Diego, CA, 353226), CD45RA‐APC (clone 5H9, BD Biosciences, Franklin Lakes, NJ, 561210), and Viability Dye eFluor780 (APC‐Cy7, eBioscience, San Diego, CA, 65‐0865).

    Techniques: Clinical Proteomics, Recombinant

    KPD model differential equations.

    Journal: CPT: Pharmacometrics & Systems Pharmacology

    Article Title: Translational kinetic‐pharmacodynamics of mRNA‐6231, an investigational mRNA therapeutic encoding mutein interleukin‐2

    doi: 10.1002/psp4.13142

    Figure Lengend Snippet: KPD model differential equations.

    Article Snippet: Flow cytometry to assess the expansion of T regs used several markers including the IL‐2 [Human] V‐Plex Kit (MesoScale Discovery, Rockville, MD, K151QQ), CD25‐BV421 (clone M‐A251, BioLegend, San Diego, CA, 356114), CD16‐BV510 (Clone 3G8, BioLegend, San Diego, CA, 302042), CD4‐BV711 (clone OKT4, BioLegend, San Diego, CA, 317440), CD8‐BV785 (clone SK1, BioLegend, San Diego, CA, 344740), CD3‐AF488 (clone SP34‐2, BD Biosciences, Franklin Lakes, NJ, 557705), FoxP3‐PE (clone 206D, BioLegend, San Diego, CA, 320108f), CD14‐PerCP‐Cy5.5 (clone M5E2, BioLegend, San Diego, CA, 301824), CCR7‐PE‐Cy7 (clone G043H7, BioLegend, San Diego, CA, 353226), CD45RA‐APC (clone 5H9, BD Biosciences, Franklin Lakes, NJ, 561210), and Viability Dye eFluor780 (APC‐Cy7, eBioscience, San Diego, CA, 65‐0865).

    Techniques: Injection, Concentration Assay

    KPD model parameter estimates.

    Journal: CPT: Pharmacometrics & Systems Pharmacology

    Article Title: Translational kinetic‐pharmacodynamics of mRNA‐6231, an investigational mRNA therapeutic encoding mutein interleukin‐2

    doi: 10.1002/psp4.13142

    Figure Lengend Snippet: KPD model parameter estimates.

    Article Snippet: Flow cytometry to assess the expansion of T regs used several markers including the IL‐2 [Human] V‐Plex Kit (MesoScale Discovery, Rockville, MD, K151QQ), CD25‐BV421 (clone M‐A251, BioLegend, San Diego, CA, 356114), CD16‐BV510 (Clone 3G8, BioLegend, San Diego, CA, 302042), CD4‐BV711 (clone OKT4, BioLegend, San Diego, CA, 317440), CD8‐BV785 (clone SK1, BioLegend, San Diego, CA, 344740), CD3‐AF488 (clone SP34‐2, BD Biosciences, Franklin Lakes, NJ, 557705), FoxP3‐PE (clone 206D, BioLegend, San Diego, CA, 320108f), CD14‐PerCP‐Cy5.5 (clone M5E2, BioLegend, San Diego, CA, 301824), CCR7‐PE‐Cy7 (clone G043H7, BioLegend, San Diego, CA, 353226), CD45RA‐APC (clone 5H9, BD Biosciences, Franklin Lakes, NJ, 561210), and Viability Dye eFluor780 (APC‐Cy7, eBioscience, San Diego, CA, 65‐0865).

    Techniques: Concentration Assay